ALLAH NAMES

Sunday, April 17, 2011

List of antibiotics

Following is a list of antibiotics, sorted by class. The highest division is between bactericidal antibiotics and bacteriostatic antibiotics. Bactericidals kill bacteria directly where bacteriostatics prevent them from dividing. However, these classifications are based on laboratory behavior; in practice, both of these are capable of ending a bacterial infection.[1]
See also pathogenic bacteria for a list of antibiotics sorted by target bacteria.
Antibiotics by class
Generic name Brand names Common uses[2] Possible side effects[2] Mechanism of action
Aminoglycosides
Amikacin Amikin Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against Aerobic bacteria (not obligate/facultative anaerobes) and tularemia. Binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.
Gentamicin Garamycin
Kanamycin Kantrex
Neomycin Mycifradin
Netilmicin Netromycin
Tobramycin Nebcin
Paromomycin Humatin
Ansamycins
Geldanamycin
Experimental, as antitumor antibiotics

Herbimycin
Carbacephem
Loracarbef Lorabid Discontinued
prevents bacterial cell division by inhibiting cell wall synthesis.
Carbapenems
Ertapenem Invanz Bactericidal for both Gram-positive and Gram-negative organisms and therefore useful for empiric broad-spectrum antibacterial coverage. (Note MRSA resistance to this class.)
  • Gastrointestinal upset and diarrhea
  • Nausea
  • Seizures
  • Headache
  • Rash and allergic reactions
Inhibition of cell wall synthesis
Doripenem Doribax
Imipenem/Cilastatin Primaxin
Meropenem Merrem
Cephalosporins (First generation)
Cefadroxil Duricef Good coverage against Gram positive infections.
  • Gastrointestinal upset and diarrhea
  • Nausea (if alcohol taken concurrently)
  • Allergic reactions
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Cefazolin Ancef
Cefalotin or Cefalothin Keflin
Cefalexin Keflex
Cephalosporins (Second generation)
Cefaclor Ceclor Less gram positive cover, improved gram negative cover.
  • Gastrointestinal upset and diarrhea
  • Nausea (if alcohol taken concurrently)
  • Allergic reactions
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Cefamandole Mandol
Cefoxitin Mefoxin
Cefprozil Cefzil
Cefuroxime Ceftin, Zinnat
Cephalosporins (Third generation)
Cefixime Suprax Improved coverage of Gram negative organisms, except Pseudomonas. Reduced Gram positive cover.
  • Gastrointestinal upset and diarrhea
  • Nausea (if alcohol taken concurrently)
  • Allergic reactions
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Cefdinir Omnicef, Cefdiel
Cefditoren Spectracef
Cefoperazone Cefobid
Cefotaxime Claforan
Cefpodoxime Vantin
Ceftazidime Fortaz
Ceftibuten Cedax
Ceftizoxime Cefizox
Ceftriaxone Rocephin
Cephalosporins (Fourth generation)
Cefepime Maxipime Covers pseudomonal infections.
  • Gastrointestinal upset and diarrhea
  • Nausea (if alcohol taken concurrently)
  • Allergic reactions
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Cephalosporins (Fifth generation)
Ceftobiprole Zeftera Used to treat MRSA
  • Gastrointestinal upset and diarrhea
  • Nausea (if alcohol taken concurrently)
  • Allergic reactions
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Glycopeptides
Teicoplanin Targocid

inhibiting peptidoglycan synthesis
Vancomycin Vancocin
Telavancin Vibativ
Lincosamides
Clindamycin Cleocin Serious staph-, pneumo-, and streptococcal infections in penicillin-allergic patients, also anaerobic infections; clindamycin topically for acne Possible C. difficile-related pseudomembranous enterocolitis Bind to 50S subunit of bacterial RNA thereby inhibiting protein synthesis
Lincomycin Lincocin
Lipopeptide
Daptomycin Cubicin Gram-positive organisms
Bind to the membrane and cause rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis
Macrolides
Azithromycin Zithromax, Sumamed, Zitrocin Streptococcal infections, syphilis, upper respiratory tract infections, lower respiratory tract infections, mycoplasmal infections, Lyme disease
  • Nausea, vomiting, and diarrhea (especially at higher doses)
  • Jaundice
inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA.
Clarithromycin Biaxin
Dirithromycin Dynabac
Erythromycin Erythocin, Erythroped
Roxithromycin
Troleandomycin TAO
Telithromycin Ketek Pneumonia Visual Disturbance, Liver Toxicity.[3]
Spectinomycin Trobicin Gonorrhea
Monobactams
Aztreonam Azactam

Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Nitrofurans
Furazolidone Furoxone Bacterial or protozoal diarrhea or enteritis

Nitrofurantoin Macrodantin, Macrobid Urinary tract infections

Penicillins
Amoxicillin Novamox, Amoxil Wide range of infections; penicillin used for streptococcal infections, syphilis, and Lyme disease
  • Gastrointestinal upset and diarrhea
  • Allergy with serious anaphylactic reactions
  • Brain and kidney damage (rare)
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Ampicillin Principen
Azlocillin
Carbenicillin Geocillin
Cloxacillin Tegopen
Dicloxacillin Dynapen
Flucloxacillin Floxapen
Mezlocillin Mezlin
Methicillin Staphcillin
Nafcillin Unipen
Oxacillin Prostaphlin
Penicillin G Pentids
Penicillin V Pen-Vee-K
Piperacillin Pipracil
Temocillin Negaban
Ticarcillin Ticar
Penicillin combinations
Amoxicillin/clavulanate Augmentin

The second component prevents bacterial resistance to the first component
Ampicillin/sulbactam Unasyn
Piperacillin/tazobactam Zosyn
Ticarcillin/clavulanate Timentin
Polypeptides
Bacitracin
Eye, ear or bladder infections; usually applied directly to the eye or inhaled into the lungs; rarely given by injection Kidney and nerve damage (when given by injection) Inhibits isoprenyl pyrophosphate, a molecule that carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane [4]
Colistin Coly-Mycin-S Interact with the gram negative bacterial outer membrane and cytoplasmic membrane. It displaces bacterial counter ions, which destabilizes the outer membrane. They act like a detergent against the cytoplasmic membrane, which alters its permeability. Polymyxin B and E are bactericidal even in an isosmotic solution.
Polymyxin B
Quinolones
Ciprofloxacin Cipro, Ciproxin, Ciprobay Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare) inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription.
Enoxacin Penetrex
Gatifloxacin Tequin
Levofloxacin Levaquin
Lomefloxacin Maxaquin
Moxifloxacin Avelox
Nalidixic acid NegGram
Norfloxacin Noroxin
Ofloxacin Floxin, Ocuflox
Trovafloxacin Trovan Withdrawn
Grepafloxacin Raxar Withdrawn
Sparfloxacin Zagam Withdrawn
Temafloxacin Omniflox Withdrawn
Sulfonamides
Mafenide Sulfamylon Urinary tract infections (except sulfacetamide, used for eye infections, and mafenide and silver sulfadiazine, used topically for burns) Folate synthesis inhibition. They are competitive inhibitors of the enzyme dihydropteroate synthetase, DHPS. DHPS catalyses the conversion of PABA (para-aminobenzoate) to dihydropteroate, a key step in folate synthesis. Folate is necessary for the cell to synthesize nucleic acids (nucleic acids are essential building blocks of DNA and RNA), and in its absence cells will be unable to divide.
Sulfonamidochrysoidine (archaic) Prontosil
Sulfacetamide Sulamyd, Bleph-10
Sulfadiazine Micro-Sulfon
Silver sulfadiazine Silvadene
Sulfamethizole Thiosulfil Forte
Sulfamethoxazole Gantanol
Sulfanilimide (archaic)
Sulfasalazine Azulfidine
Sulfisoxazole Gantrisin
Trimethoprim Proloprim, Trimpex
Trimethoprim-Sulfamethoxazole (Co-trimoxazole) (TMP-SMX) Bactrim, Septra
Tetracyclines
Demeclocycline Declomycin Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, *malaria *Note: Malaria is caused by a protist and not a bacterium.
  • Gastrointestinal upset
  • Sensitivity to sunlight
  • Potential toxicity to mother and fetus during pregnancy
  • Enamel hypoplasia (staining of teeth; potentially permanent)
  • transient depression of bone growth
inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex.
Doxycycline Vibramycin
Minocycline Minocin
Oxytetracycline Terramycin
Tetracycline Sumycin, Achromycin V, Steclin
Drugs against mycobacteria
Clofazimine Lamprene Antileprotic

Dapsone Avlosulfon Antileprotic

Capreomycin Capastat Antituberculosis

Cycloserine Seromycin Antituberculosis, urinary tract infections

Ethambutol Myambutol Antituberculosis

Ethionamide Trecator Antituberculosis
Inhibits peptide synthesis
Isoniazid I.N.H. Antituberculosis

Pyrazinamide Aldinamide Antituberculosis

Rifampicin (Rifampin in US) Rifadin, Rimactane mostly Gram-positive and mycobacteria Reddish-orange sweat, tears, and urine Binds to the β subunit of RNA polymerase to inhibit transcription
Rifabutin Mycobutin Mycobacterium avium complex rash, discolored urine, GI symptoms
Rifapentine Priftin Antituberculosis

Streptomycin
Antituberculosis Neurotoxicity, ototoxicity As other aminoglycosides
Others
Arsphenamine Salvarsan Spirochaetal infections (obsolete)

Chloramphenicol Chloromycetin meningitis, MRSA, topical use, or for low cost internal treatment. Historic: typhus, cholera. gram negative, gram positive, anaerobes Rarely: aplastic anemia. Inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome
Fosfomycin Monurol Acute cystitis in women
Inactivates enolpyruvyl transferase, thereby blocking cell wall synthesis
Fusidic acid Fucidin


Linezolid Zyvox VRSA

Metronidazole Flagyl Infections caused by anaerobic bacteria; also amoebiasis, trichomoniasis, Giardiasis Discolored urine, headache, metallic taste, nausea ; alcohol is contraindicated Produces toxic free radicals which disrupt DNA and proteins. This non-specific mechanism is responsible for its activity against a variety of bacteria, amoebae, and protozoa.
Mupirocin Bactroban Ointment for impetigo, cream for infected cuts

Platensimycin



Quinupristin/Dalfopristin Synercid


Rifaximin Xifaxan Traveler's diarrhea caused by E. coli

Thiamphenicol
Gram-negative, Gram-positive, anaerobes. widely used in veterinary medicine. Lacks known anemic side-effects. A chloramphenicol analog. May inhibit bacterial protein synthesis by binding to the 50S subunit of the ribosome
Tigecycline Tigacyl


Tinidazole Tindamax Fasigyn protozoan infections upset stomach, bitter taste, and itchiness
Generic Name Brand Names Common Uses[2] Possible Side Effects[2] Mechanism of action

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